Antiviral therapy in shrimp through plant virus VLP containing VP28 dsRNA against WSSV
نویسندگان
چکیده
منابع مشابه
The utilization of VP28 gene to protect penaeid shrimps from white spot syndrome virus disease: a review
White spot syndrome (WSS) is a viral disease which affects most of the commercially cultivated marine shrimp species all over the world causing significant losses. Deaths occur within days of symptoms and affect a diverse range of commercial crustacean species. A heavy mortality is usually observed in the entire infected population. Survival rates can be anywhere from 30% to zero. Consequently,...
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White spot syndrome (WSS) is one of the most common and most disastrous diseases of shrimp worldwide. It causes up to 100% mortality within 3 to 4 days in commercial shrimp farms, resulting in large economic losses to the shrimp farming industry. VP28 envelope protein of WSSV is reported to play a key role in the systemic infection in shrimps. Considering the most sombre issue of viral disease ...
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Introduction: White spot syndrome virus (WSSV) is one of the most deadly infectious pathogens of the shrimp culture industry. Neither effective vaccines nor efficient treatments are currently available for this disease. Vibrio species are well known dominant bacterial pathogens in the shrimp ponds. As facultative pathogenic bacteria, it is possible that Vibrio spp. along with WSSV to co-infect ...
متن کاملOral Vaccination of Baculovirus-Expressed VP28 Displays Enhanced Protection against White Spot Syndrome Virus in Penaeus monodon
White Spot Syndrome Virus (WSSV) is an infectious pathogen of shrimp and other crustaceans, and neither effective vaccines nor adequate treatments are currently available. WSSV is an enveloped dsDNA virus, and one of its major envelope proteins, VP28, plays a pivotal role in WSSV infection. In an attempt to develop a vaccine against WSSV, we inserted the VP28 gene into a baculovirus vector tail...
متن کاملLarge-scale production and antiviral efficacy of multi-target double-stranded RNA for the prevention of white spot syndrome virus (WSSV) in shrimp
BACKGROUND RNA interference (RNAi) is a specific and effective approach for inhibiting viral replication by introducing double-stranded (ds)RNA targeting the viral gene. In this study, we employed a combinatorial approach to interfere multiple gene functions of white spot syndrome virus (WSSV), the most lethal shrimp virus, using a single-batch of dsRNA, so-called "multi-WSSV dsRNA." A co-culti...
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ژورنال
عنوان ژورنال: Beilstein Journal of Organic Chemistry
سال: 2021
ISSN: 1860-5397
DOI: 10.3762/bjoc.17.95